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目的首次报道伏立康唑成功治疗1例红色毛癣菌引起的顽固性面部Majocchi肉芽肿,分析患者的临床表现、病理特点、真菌学检查及分子生物学鉴定结果,并总结英文报道病例。方法患者男,50岁,因面部浸润性红斑溃疡5a就诊,取患处皮损进行组织病理学检查、真菌学检查、药物敏感试验及PCR检测。结果诊断:红色毛癣菌致面部Majocchi肉芽肿。治疗:伏立康唑静脉治疗2周改伏立康唑片剂口服,治疗4个月后患者原有皮损基本消退,真菌学阴性,无不良反应。结论 Majocchi肉芽肿临床罕见,复杂难治,疗程长,易反复,严重影响患者生活质量,我们首次应用伏立康唑成功治疗顽固性Majocchi肉芽肿,为临床治疗难治性Majocchi肉芽肿提供新的诊疗经验。
OBJECTIVE: To report the clinical results, pathological features, mycological examination and molecular biological identification results of voriconazole in the treatment of intractable facial Majocchi granuloma caused by Trichophyton rubrum, and to summarize the reported cases in English. Methods Male, 50 years old, were treated with facial infiltrative erythematous ulcer 5a. Histopathological examination, mycological examination, drug susceptibility test and PCR were performed on the lesion. Results Diagnosis: Trichophyton rubrum caused facial Majocchi granuloma. Treatment: Voriconazole intravenous therapy Voriconazole tablets were taken orally 2 weeks after treatment, the original skin lesions in patients after 4 months of treatment subsided, mycology negative, no adverse reactions. Conclusions Majocchi granuloma is a rare and complicated refractory, long-course and easy-to-be repeated treatment, which seriously affects the quality of life of patients. The first successful application of voriconazole in the treatment of intractable Majocchi granulomatosis provided new experience in clinical treatment of refractory Majocchi granuloma.