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本文采用搅拌法制备吡罗昔康与β-环糊精(β-CD)包合物。制备包合物的最佳搅拌时间为5.5h;3批包合物含量均为22～23%;包合物的主、客分子比为1∶1。样品用 X-射线衍射法及 NMR法测定证明炎痛喜康与β-CD 确已形成包合物,炎痛喜康的苯环部分被包入β-CD 空腔内。
In this paper, piroxicam and β-cyclodextrin (β-CD) inclusion complexes were prepared by a stirring method. The optimum mixing time for preparation of the inclusion compound was 5.5 h. The content of the three batches of the inclusion compounds was 22-23%. The main and guest molecular ratio of the inclusion compound was 1: 1. The samples were characterized by X-ray diffractometry and NMR spectroscopy. It was confirmed that YK and β-CD did form an inclusion compound. The YHF part of the phenyl ring was encapsulated in β-CD cavity.