【摘 要】
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Human cytomegalovirus (HCMV) infection is common and affects between 40-100％ of the worldwide population. However, the majority of cases are asymptomatic and whe
【机 构】
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Department of Medicine, Division of Gastroenterology-Hepatology, University of Connecticut Health Ce
论文部分内容阅读
Human cytomegalovirus (HCMV) infection is common and affects between 40-100％ of the worldwide population. However, the majority of cases are asymptomatic and when severe disease occurs, it is usually restricted to immuno-compromised patients. Liver involvement by HCMV differs significantly, accordingly to the immune status of the host. In immunocompromised patients, particularly liver trans-plant patients, it often causes clinically significant hepatitis. On the other hand, in immunocompetent patients, HCMV hepatitis requiring hospitalization is extremely rare. This review aims to appraise studies regarding the pathophysiol-ogy of HCMV hepatitis, including mechanisms of latency and reactivation and its contribution to disease development, clinical presentation, diagnostic modalities and treatment, with a focus on comparing different aspects between immu-nocompromised and immunocompetent hosts.
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