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首先需要指出,加温治疗肿瘤主要应利用其细胞毒性作用,而不应把加温当作放射增敏剂使用。固然,适量加温对细胞有放射增敏作用,但是这种增敏作用对肿瘤和正常组织等效,既增强肿瘤的放射效应,也增强正常组织的放射效应,不利于肿瘤治疗;而加温对肿瘤的细胞毒性作用明显大于对正常组织的作用,因之使加温治疗肿瘤更为安全有效。在本讲结束后,将会对这个结论有更深刻的理解。 1963年Crile使用热水加温,以后开展了一系列研究(Robinson等1972,Muckle等1973,Thrall等1975,Suit1976,Stewart1977及Hill1977)。其他加温方法除微波(透热疗法Overgaard等1972)、射频(Marmor等)外,还有热空气法(Yeruhaimi等1974)、红外线加温(HahnE.1974)、超声加热(HahnG.)等,但所有的加温方法
First of all, it should be pointed out that the treatment of tumors with warming should mainly use its cytotoxic effect, and should not be used as a radiosensitizer. Of course, moderate warming has a radiosensitizing effect on cells, but this sensitizing effect is equivalent to tumor and normal tissue, which not only enhances the radiation effect of tumors, but also enhances the radiation effect of normal tissues, which is not conducive to tumor therapy; The cytotoxic effect on tumors is significantly greater than that on normal tissues, which makes it safer and more effective to treat tumors with warming. After the conclusion of this lecture, we will have a deeper understanding of this conclusion. Crile used hot water heating in 1963 and later carried out a series of studies (Robinson et al. 1972, Muckle et al. 1973, Thrall et al. 1975, Suit 1976, Stewart 1977 and Hill 1977). Other methods of warming include microwaves (diathermy Overgaard et al. 1972), radio frequency (Marmor et al.), hot air methods (Yeruhaimi et al. 1974), infrared heating (Hahn E.1974), ultrasonic heating (Hahn G.), and the like. But all the heating methods