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目的探讨富马酸比索洛尔对慢性肺源性心脏病心律失常患者脑钠肽(BNP)、C-反应蛋白(CRP)水平的影响。方法选择2014年3月至2015年9月慢性肺源性心脏病心律失常患者102例为研究对象,按随机数表法将其分为对照组和观察组,每组51例。对照组实施盐酸地尔硫卓治疗,观察组实施富马酸比索洛尔治疗。比较两组患者治疗前、治疗后1个月的BNP、CRP水平以及临床疗效。结果治疗前两组BNP、CRP水平比较差异未见统计学意义(P>0.05);治疗后两组BNP、CRP水平较治疗前均有明显改善,且观察组水平低于对照组,差异有统计学意义(P<0.05);观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。结论对慢性肺源性心脏病心律失常患者实施富马酸比索洛尔治疗效果显著,能有效提高临床疗效,改善BNP、CRP水平,在临床应用中具有较高的推广价值。
Objective To investigate the effects of bisoprolol fumarate on the levels of brain natriuretic peptide (BNP) and C-reactive protein (CRP) in patients with chronic cor pulmonale of heart disease. Methods From March 2014 to September 2015, 102 patients with chronic cor pulmonale and cardiac arrhythmia were enrolled in this study. According to the random number table, they were divided into control group and observation group, with 51 cases in each group. The control group was treated with diltiazem hydrochloride and the observation group was treated with bisoprolol fumarate. The levels of BNP and CRP in both groups before treatment and one month after treatment were compared and the clinical efficacy was compared. Results There was no significant difference in BNP and CRP levels between the two groups before treatment (P> 0.05). After treatment, the levels of BNP and CRP in both groups were significantly improved compared with that before treatment, and the levels in observation group were lower than those in control group (P <0.05). The effective rate of observation group was higher than that of control group, the difference was statistically significant (P <0.05). Conclusions The treatment of bisoprolol fumarate in patients with chronic cor pulmonale with cardiac arrhythmia is significant, which can effectively improve the clinical curative effect, improve the levels of BNP and CRP, and have a high popularization value in clinical application.