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囊性纤维性变(CF)是一种致死性、遗传性疾病,目前尚无有效的治疗方法。多数CF的发病和死亡与绿脓杆菌(PA)慢性肺感染有关。因此了解PA的微生物学特性,与宿主间的相互作用及PA所致肺损伤的发病机制非常重要。PA是一种条件致病菌,但是一经感染,其毒力很强,它能分泌多种菌体外产物,玻坏宿主的免疫功能,同时产生藻酸盐,直接或间接地损伤肺组织,使肺功能衰退。CF的成功治疗是基因治疗,但目前尚不能采用。通过适当的免疫疗法、抗生素治疗及免疫调节,可防止PA栖生,根除肺内PA,改善体质,延长CF病人的生存。
Cystic fibrosis (CF) is a fatal, genetic disease, there is no effective treatment. Most CF morbidity and mortality are associated with Pseudomonas aeruginosa (PA) chronic lung infections. It is therefore important to understand the microbiological characteristics of PA, its interaction with the host, and the pathogenesis of PA-induced lung injury. PA is a pathogenic bacteria, but once infected, its virulence is very strong, it can secrete a variety of extracellular products, damage the host immune function, while alginate, directly or indirectly damage the lung tissue, So that lung function decline. The successful treatment of CF is gene therapy, but it is not yet available. Through appropriate immunotherapy, antibiotic treatment and immune regulation, to prevent PA habitat, the eradication of pulmonary PA, improve physical fitness and extend the survival of CF patients.