新近研究指出;组织经长期或反复暴露于β-肾上腺素能激动药可降低其对肾上腺素能激动药进一步刺激的反应性。无论在体内或者体外试验,组织一旦暴露于各种不同的肾上腺素能激动药,均可产生此种现象。这种现象的产生通常是由于激素特异性的敏感性降低或者是β-肾上腺素能受体产生了耐受性的缘故。受体反应性的降低常常作为一种有效的内环境稳定 Recent research indicates that long-term or repeated exposure of tissues to beta-adrenergic agonists reduces their reactivity to further stimulation of adrenergic agonists. This phenomenon can occur once the tissue is exposed to various adrenergic agonists, either in vivo or in vitro. This phenomenon is usually caused by a decrease in hormone-specific sensitivity or a tolerance of β-adrenergic receptors. Reduced receptor reactivity is often used as an effective homeostasis