论文部分内容阅读
目的探讨急性脑梗塞时免疫作用机制。方法对７０例急性缺血性脑血管病患者血清白细胞介素－１、白细胞介素－６、肿瘤坏死因子水平进行了测定，并同４６名健康人作对照比较。结果急性脑梗塞和ＴＩＡ患者组上述指标均高于对照组（Ｐ＜０．０５）；脑梗塞和ＴＩＡ两组间比较ＩＬ－１、ＴＮＦ也有显著性差异（Ｐ＜０．０５、Ｐ＜０．００１）。各指标水平与梗塞部位无关。神经功能重度受损者的ＩＬ－１、ＴＮＦ明显高于轻度神经功能受损者（Ｐ＜０．０１、Ｐ＜０．０５）。动态观察到在发病第１天与第４、７天的ＩＬ－１、ＴＮＦ相比有显著性差异（Ｐ＜０．０１）。结论在缺血性脑血管病的发病机理中有免疫机制的参与
Objective To investigate the mechanism of immune function in acute cerebral infarction. Methods The levels of serum interleukin-1, interleukin-6 and tumor necrosis factor-α in 70 patients with acute ischemic cerebrovascular disease were measured and compared with 46 healthy controls. Results The levels of IL-1 and TNF in cerebral infarction and TIA groups were significantly higher than those in control group (P <0.05, P <0.05) .001). The level of each index has nothing to do with the infarction site. The levels of IL-1 and TNF in patients with severe neurological impairment were significantly higher than those with mild neurological impairment (P <0.01, P <0.05). Dynamic observation showed that there was a significant difference (P <0.01) between IL-1 and TNF on day 1 and day 4 and 7 of onset. Conclusion There is an immune mechanism involved in the pathogenesis of ischemic cerebrovascular disease