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AIM:TO investigate whether vascular endothelial growthfactor(VEGF)and basic fibroblastic growth factor(bFGF)areassociated with spider angiomas in patients with liver cirrhosis.METHODS:Eighty-six patients with liver cirrhosis wereenrolled and the number and size of the spider angiomaswere recorded.Fifty-three healthy subjects were selectedas controls.Plasma levels of VEGF and bFGF were measuredin both the cirrhotics and the controls.RESULTS:Plasma VEGF and bFGF were increased in cirrhoticscompared with controls(122±13 vs.71±11 pg/mL,P=0.003for VEGF;5.1±0.5 vs.3.4±0.5 pg/mL,P=0.022 for bFGF).Incirrhotics,plasma VEGF and bFGF were also higher in patientswith spider angiomas compared with patients without spiderangiomas(185±28 vs.90±10 pg/mL,P=0.003 for VEGF;6.8±1.0 vs.4.1±0.5 pg/mL,P=0.017 for bFGF).Multivariatelogistic regression showed that young age and increasedplasma levels of VEGF and bFGF were the most significantpredictors for the presence of spider angiomas in cirrhoticpatients(odds ratio[OR]=6.64,95 % confidence interval[CI]=2.02-21.79,P=0.002;OR=4.35,95 % CI=1.35-14.01,P=0.014;OR=5.66,95 % CI=1.72-18.63,P=0.004,respectively).CONCLUSION: Plasma VEGF and bFGF are elevated in patients with liver cirrhosis. Age as well as plasma levels of VEGF and bFGF are significant predictors for spider angiomas in cirrhotic patients.
AIM: TO investigate whether vascular endothelial growth factor (VEGF) and basic fibroblastic growth factor (bFGF) areassociated with spider angiomas in patients with liver cirrhosis. METHODS: Eighty-six patients with liver cirrhosis were induced and the number and size of the spider angiomaswere recorded. Plasma levels of VEGF and bFGF were increased in cirrhoticscompared with controls (122 ± 13 vs.71 ± 11 pg / mL, P = 0.003 for VEGF; 5.1 ± 0.5 vs.3.4 ± 0.5 pg / mL, P = 0.022 for bFGF) .Incirrhotics, plasma VEGF and bFGF were also higher in patients with spider angiomas compared with patients without spiderangiomas (185 ± 28 vs.90 ± 10 pg / mL, P = 0.003 for VEGF; 6.8 ± 1.0 vs. 4.1 ± 0.5 pg / mL, P = 0.017 for bFGF) .Multivariate logistic regression showed that young age and increased plasma levels of VEGF and bFGF were the most significant predictors for the presence of spider angiomas in cirrhoticpa t odds ratio [OR] = 6.64, 95% confidence interval [CI] = 2.02-21.79, P = 0.002; OR = 4.35, 95% CI = 1.35-14.01, P = 0.014; OR = 5.66, 95% CI = 1.72-18.63, P = 0.004, respectively). CONCLUSION: Plasma VEGF and bFGF are elevated in patients with liver cirrhosis. Age as well as plasma levels of VEGF and bFGF are significant predictors for spider angiomas in cirrhotic patients.