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目的研究早期结直肠癌中p27kip1蛋白的表达情况,探讨肿瘤组织中p27kip1的表达差异在早期结直肠癌预后评价中的意义。方法应用免疫组织化学方法检测114例早期结直肠癌组织中p27kip1的表达水平,应用SPSS10．0软件分析p27kip1表达差异与预后的相关性。结果在早期结直肠癌中p27kip1蛋白高表达率为85．1％(97／114);p27kip1表达水平与肿瘤组织学分级、TNM分期显著相关,而与患者年龄、肿瘤部位等无关(P>0．05);p27kip1高表达组病例根治术后五年无瘤生存率明显高于低表达组病例(88．40％vs．52．94％,P<0．01);多因素分析显示p27kip1与肿瘤组织学分级均为早期结直肠癌的独立预后因素。结论p27kip1蛋白高表达在早期结直肠癌中较为常见,其表达水平是早期结直肠癌的独立预后因素之一;p27kip1可以作为评价患者预后的重要参考指标。
Objective To study the expression of p27kip1 protein in early stage colorectal cancer and to explore the significance of the difference of p27kip1 expression in the prognosis evaluation of early stage colorectal cancer. Methods The expression of p27kip1 in 114 cases of early stage colorectal cancer was detected by immunohistochemistry. The correlation between p27kip1 expression and prognosis was analyzed by SPSS10.0 software. Results The high expression rate of p27kip1 in early colorectal cancer was 85.1% (97/114). The expression level of p27kip1 was significantly correlated with histological grade and TNM stage, but not with age, tumor location, etc. (P> 0 .05). The 5-year disease-free survival rate of patients with high expression of p27kip1 was significantly higher than that of patients with low expression (88.40% vs.52.94%, P <0.01). Multivariate analysis showed that p27kip1 and Tumor histological grade were independent prognostic factors for early colorectal cancer. Conclusion The high expression of p27kip1 protein is more common in early stage colorectal cancer. The expression level of p27kip1 is one of the independent prognostic factors of early stage colorectal cancer. P27kip1 can be used as an important reference index to evaluate the prognosis of patients.