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我们已经报道了同时带有咪唑基、羧基和羟基三种功能团的糖淀粉衍生物(CHA)能有效地催化N-十二烷基-3-乙酰氧基吡啶盐碘化物(DAPI)的水解,并推断出反应系在螺旋端部进行。如果受物的反应部位进入了螺旋内穴,情况又会怎样呢?本工作通过使用三种不同的受物,N-十二烷基-2-氧代吡啶盐碘化物(DCPI,1),N-十二烷基-3-乙酰氧基吡啶盐碘化物(DAPI,2)和对硝基苯酚月桂酸酯(PNPL,3)和改变糖淀粉链上悬挂功能团的尺寸来回答上述问题。
We have reported that glycosylated starch derivatives (CHA), which possess three functional groups, imidazolyl, carboxyl and hydroxyl, can effectively catalyze the hydrolysis of N-dodecyl-3-acetoxypyridinium iodide (DAPI) , And concluded that the reaction was at the helical end. What would happen if the reaction site of the receptor entered the spiral pocket? This work was conducted by using three different receptors, N-dodecyl-2-oxopyridinium iodide (DCPI, 1) N-dodecyl-3-acetoxypyridinium iodide (DAPI, 2) and p-nitrophenol laurate (PNPL, 3) and changing the size of the dangling functional groups on the sugar starch chains.