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目的:研究急性心肌梗死(AMI)后联合使用阿司匹林和血管紧张素转换酶抑制剂或血管紧张素Ⅱ受体拮抗剂(ACEI)对病死率的影响。方法:对116例AMI伴心力衰竭(心衰)病人进行随访(平均随访253d)以确定转归,回顾性分析AMI病人有关病史及治疗措施,进行Cox多因素生存分析及卡方分析。结果:阿司匹林、ACEI与AMI病死率独立相关。未用阿司匹林和ACEI组、单用阿司匹林或ACEI组、阿司匹林与ACEI合用组病死率分别是89.3%、62.2%、35.3%,3组之间差异有显著性。结论:阿司匹林与ACEI合用比单用更有助于降低AMI病死率。
Objective: To investigate the effect of aspirin and angiotensin converting enzyme inhibitor or angiotensin Ⅱ receptor antagonist (ACEI) combined with aspirin on the mortality after acute myocardial infarction (AMI). Methods: A total of 116 AMI patients with heart failure (HF) were followed up (mean follow-up 253 days) to determine the outcome. The history and treatment of AMI were retrospectively analyzed. Cox multivariate survival analysis and Chi-square analysis were performed. Results: Aspirin and ACEI were independently associated with AMI mortality. No aspirin and ACEI group, aspirin alone or ACEI group, aspirin and ACEI combined group mortality was 89.3%, 62.2%, 35.3%, the difference between the three groups were significant. Conclusion: Combination of aspirin with ACEI is more helpful than AMI in reducing AMI mortality.