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目的 观察乌拉地尔用于预防颅脑手术麻醉拔管期高血压应激反应的效应。方法 40例择期颅脑手术患者 ,随机分为治疗组与对照组 ,各 2 0例。在麻醉清醒期分别静注乌拉地尔 0 4mg/kg或生理盐水 0 0 8ml/kg。记录注药前、注药后 1min、吸痰时、拔管时、拔管后 1,5min以及回监护室 (NICU)后的血压和心率的变化。结果 治疗组注药后各时期的血压维持均较平稳 ,与注药前比较变化无显著差异 (P >0 0 5 ) ;对照组的血压即明显升高 ,组间比较有显著性差异 (P <0 .0 5 )。结论 颅脑手术麻醉拔管期应用乌拉地尔能较好预防高血压应激反应 ,又不致术后脑组织低灌注。
Objective To observe the effect of urapidil on preventing hypertension during extubation of craniocerebral surgery. Methods Forty patients undergoing elective craniocerebral surgery were randomly divided into treatment group and control group, 20 cases each. In anesthetized awake phase, intravenous urapidil 0 4mg / kg or saline 0 0 8ml / kg respectively. The changes of blood pressure and heart rate were recorded before injection, 1 minute after injection, suctioning, extubation, 1,5 minutes after extubation and NICU. Results In the treatment group, the blood pressure maintained at a steady level during each period after injection, and there was no significant difference between before and after treatment (P> 0.05). The blood pressure of the control group was significantly increased, and there was significant difference between the two groups (P <0 .0 5). Conclusion The application of urapidil during craniocerebral anesthesia during extubation can better prevent the hypertensive stress response and not cause postoperative low perfusion of brain tissue.