论文部分内容阅读
目的 探讨转化生长因子 -β1(TGF -β1)在大肠癌分化、转移中的作用。方法 应用免疫组织化学方法检测 42例大肠癌手术标本的TGF -β1的蛋白表达。结果 ⑴低分化大肠癌组织中TGF -β1的蛋白表达水平明显高于高分化组 ,差异有显著性 (P <0 0 1) ;⑵伴有淋巴转移和肝转移的大肠癌组织中TGF -β1蛋白表达水平显著增高 ,差异有显著性 (P <0 0 5 )。结论 TGF -β1大肠癌的分化、转移密切相关 ,TGF -β1蛋白表达的增强是大肠癌预后不良的一个标志
Objective To investigate the role of transforming growth factor-β1 (TGF-β1) in the differentiation and metastasis of colorectal cancer. Methods Immunohistochemistry was used to detect the protein expression of TGF-β1 in 42 cases of colorectal cancer. Results (1) The protein expression of TGF-β1 in poorly differentiated colorectal cancer was significantly higher than that in well-differentiated group (P <0.01); ⑵ The expression of TGF-β1 in colorectal cancer with lymphatic metastasis and liver metastasis The protein expression level was significantly higher, the difference was significant (P <0 05). Conclusion The differentiation and metastasis of TGF-β1 colorectal cancer are closely related. The enhancement of TGF-β1 protein expression is a sign of poor prognosis of colorectal cancer