目的　观察和探讨静脉注射丙种球蛋白 ( IVIG)对复发性肾病综合征的临床价值。 方法 　对 1995年 1月～ 2 0 0 3年 12月在我院儿科住院的复发性肾病综合征 76例 ,在激素治疗同时 ,其中 3 5例 (治疗组 )给予大剂量静脉丙种球蛋白治疗 ,剂量 2 0 0～ 40 0 mg/( kg.d) ,连用 3～ 5 d,其余 41例 (对照组 )未给予静脉注射丙种球蛋白治疗 ,观察感染部位和感染控制时间 ,浮肿消失天数 ,尿蛋白转阴时间 ,血清 Ig G、白蛋白、球蛋白。结果 　 76例复发的肾病综合征患儿 ,合并呼吸道感染 5 4例 ,泌尿系感染 8例 ,口腔感染 3例 ,皮肤及软组织感染 4例 ,无感染并发症 7例。此 7例为泼尼松减至 1mg·kg- 1隔日顿服时复发。浮肿消退、尿蛋白转阴、感染控制时间、血清 Ig G,治疗组分别为 8± 1.5 ( d)、10± 5 .3 ( d)、7± 1.5( d)、8.7± 1.2 ( g·L- 1 ) ,对照组分别为 13 .7± 5 .1( d)、2 1.1± 9.2 ( d)、16± 3 .1( d)、8.3± 1.3 ( g· L- 1 ) ,除了 Ig G外 ,各项指标均有差异性 ( P<0 .0 5 )。结论 　复发性肾病综合征患儿血清 Ig G水平明显下降 ,大部分并发不同程度感染 ,感染可能是复发的主要原因 ,大剂量 IVIG,可使感染迅速控制 ,原发病得以改善 Objective To observe and investigate the clinical value of intravenous gamma globulin (IVIG) in patients with recurrent nephrotic syndrome. Methods A total of 76 patients with recurrent nephrotic syndrome who were hospitalized in our pediatric department from January 1995 to December 2003 were treated with high dose intravenous gamma globulin while 35 were treated with hormone therapy. The dose of 200 ~ 40 0 ​​mg / (kg.d), once every 3 ~ 5 d, the remaining 41 patients (control group) were not given intravenous gamma globulin treatment, the infection site and infection control time, days of edema disappear, urine Protein negative time, serum Ig G, albumin, globulin. Results 76 cases of recurrent nephrotic syndrome in children with respiratory tract infection in 54 cases of urinary tract infection in 8 cases, 3 cases of oral infections, skin and soft tissue infections in 4 cases without infection complications in 7 cases. The seven cases of prednisone reduced to 1mg · kg-1 every other day recurrence of service. Edema, urine protein negative, infection control time, serum Ig G, the treatment group were 8 ± 1.5 (d), 10 ± 5.3 (d), 7 ± 1.5 (d), 8.7 ± 1.2 - 1) and control groups were 13.7 ± 5 .1 (d), 2.1 ± 9.2 (d), 16 ± 3 .1 (d) and 8.3 ± 1.3 (g · L -1) In addition, the indicators were different (P <0.05). Conclusion Serum Ig G levels in children with recurrent nephrotic syndrome are significantly decreased, most of them complicated with different degrees of infection. Infection may be the main reason of recurrence. High dose IVIG can control the infection rapidly and the primary disease can be improved