【摘 要】
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Dear Editor,Immunodeficiency,centromeric instability,and facial anomalies (ICF) syndrome is a rare autosomal recessive disorder characterized by antibody defici
【机 构】
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Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer C
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Dear Editor,Immunodeficiency,centromeric instability,and facial anomalies (ICF) syndrome is a rare autosomal recessive disorder characterized by antibody deficiency,facial dysmorphism,failure to thrive,and mental retardation.Patients with ICF syndrome suffer from recurrent and often fatal infections in early childhood.A hallmark of ICF syndrome is loss of DNA methylation in special genomic regions,most notably satellite repeats at centromeric regions,which leads to heterochromatin decondensation and chromosomal abnormalities in lymphocytes (Ehrlich et al.,2008).
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