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肝细胞增殖的调控机制复杂,众多的细胞因子参与其中,然而,大多数的细胞因子都不具备作用的特异性,它们除了对肝细胞发挥活性作用外,还具有调控其它组织细胞的活性。Hepassocin是一种分子量为34ku的多肽,在肝切除或肝损伤后表达升高,以同源二聚体的形式在肝再生过程中发挥重要功能。与HGF、EGF等其它肝增殖相关因子不同的是:Hepassocin是一种特异性的促肝细胞增殖因子。Hepassocin的特异性主要表现在以下3方面:特异性表达于肝脏实质细胞;特异性的作用于正常肝细胞;只对肝细胞有促增殖活性,对其它组织细胞无促增殖活性,同时具有一定的种属特异性。
However, most of the cytokines do not have the specificity of action. In addition to their activity on hepatocytes, they also regulate the activity of other tissue cells. Hepassocin is a 34 ku polypeptide with increased expression after hepatectomy or hepatic injury and plays an important role in hepatic regeneration as a homodimer. And HGF, EGF and other liver proliferation related factors is different: Hepassocin is a specific pro-hepatocyte proliferation factor. Specificity of Hepassocin mainly in the following three aspects: specific expression in the liver parenchymal cells; specific role in normal liver cells; only for the proliferation of hepatocytes proliferative activity of other tissue cells without proliferative activity, but also has a certain Species-specific.