截止到目前,在人类染色体中已发现19种Wnt基因家族成员,其编码的分泌性糖蛋白含有24个保守的半胱氨酸残基,是Wnt信号传导通路的启动因素。Wnt信号传导通路有两条主要的分支:经典的Wnt/β-catenin通路和非经典的细胞极性通路/Wnt-Ca2+通路〔1-2〕。研究发现,在经典通路中,Wnt1蛋白与家族中其他成员一样,通过扩散与主动运输 Up to now, 19 members of Wnt gene family have been found in the human chromosome. The secretory glycoproteins encoded by the protein contain 24 conserved cysteine ​​residues and are the initiators of Wnt signaling pathway. The Wnt signaling pathway has two major branches: the classical Wnt / beta-catenin pathway and the nonclassical cellular polarity pathway / Wnt-Ca2 + pathway [1-2]. The study found that, in the classical pathway, Wnt1 protein and other members of the family, through the proliferation and active transport