论文部分内容阅读
目的:观察清热解毒利湿法联合小剂量来氟米特对活动性类风湿关节炎的疗效及不良反应。方法:活动期类风湿关节炎病人73例随机分成3组。治疗组口服清痹汤加减,炎琥宁320mg加入生理盐水250mL静脉点滴/d,共14天。口服来氟米特,前3天30mg/d,顿服,3天后10mg/d。对照1组:不口服来氟米特,加甲氨蝶呤(MTX)7.5mg周/,以每周2.5mg递增,最终剂量为20mg周/。对照2组:不口服来氟米特外,其余治疗方法同治疗组。治疗2个月,随访3个月,观察治疗结果及不良反应。结果:治疗组总有效率与其余两组比较有显著性差异(P<0.05)。治疗组症状、体征及红细胞沉降率(ESR)、C-反应蛋白(CRP)与对照组比较显著降低(P<0.05),治疗组未发现不良反应,对照2组发生1例不良反应。结论:清热解毒利湿法联合小剂量来氟米特对活动性类风湿关节炎疗效显著无不良反应。
Objective: To observe the efficacy and adverse reactions of detoxification and dampness combined with low-dose leflunomide on active rheumatoid arthritis. Methods: Active rheumatoid arthritis patients 73 cases were randomly divided into 3 groups. Treatment group oral Qingbi Decoction, Yan Hu Ning 320mg added saline 250mL intravenous / d, a total of 14 days. Oral leflunomide, the first 3 days 30mg / d, Dayton clothing, 3 days after 10mg / d. Control group 1: no leflunomide plus 7.5 mg of methotrexate (MTX) per week, with 2.5 mg weekly increments, with a final dose of 20 mg weekly. Control group 2: no oral leflunomide, the remaining treatment with the treatment group. Treatment for 2 months, followed up for 3 months to observe the treatment results and adverse reactions. Results: The total effective rate in the treatment group was significantly different from the other two groups (P <0.05). Symptoms and signs, erythrocyte sedimentation rate (ESR) and CRP in the treatment group were significantly lower than those in the control group (P <0.05). No adverse reactions were found in the treatment group and 1 in the control group. Conclusion: Qingrejiedu dampness combined with low-dose leflunomide in active rheumatoid arthritis significantly no adverse reactions.