论文部分内容阅读
目的分析CD4 C868T单核苷酸多态性与广西人群对HIV-Ⅰ易感性的相关性。方法选取101例广西HIV-Ⅰ型感染者(HIV-Ⅰ感染组)和102例同期同地区的健康体检者(对照组),采用聚合酶链反应(PCR)及DNA测序法,检测CD4基因C868T位点(rs28919570C/T)多态性,对rs28919570C/T基因多态性和广西人群对HIV-Ⅰ的易感性进行相关性分析。以上统计均采用SPSS 16.0软件进行分析。结果 rs28919570 C/T位点CC、CT、TT三种基因型在广西人群HIV-Ⅰ感染组和对照组中分布频率的差异无统计学意义(P>0.05)。与CC基因型相比,CT及TT基因型和HIV-Ⅰ感染风险均无相关性(P>0.05),且尚未发现rs28919570 C/T位点多态性与广西HIV-Ⅰ感染者性别差异有关。结论尚未发现rs28919570 C/T位点基因多态性与广西人群HIV-Ⅰ感染风险具有相关性。
Objective To analyze the association between CD4 C868T single nucleotide polymorphism and susceptibility to HIV-I in Guangxi. Methods 101 cases of HIV-Ⅰ infection in Guangxi (HIV-Ⅰ infection group) and 102 healthy subjects (control group) in the same period were enrolled in this study. Polymerase chain reaction (PCR) and DNA sequencing were used to detect the expression of CD4 gene C868T (Rs28919570C / T) polymorphism, the rs28919570C / T gene polymorphism and Guangxi population susceptibility to HIV-Ⅰ were analyzed. The above statistics were analyzed using SPSS 16.0 software. Results There was no significant difference in the distribution frequency of CC, CT, TT genotypes between rs28919570 C / T locus in HIV-Ⅰ infection group and control group in Guangxi population (P> 0.05). There was no correlation between genotypes of CT and TT and the risk of HIV-1 infection in CC genotypes (P> 0.05), and no association of rs28919570 C / T polymorphism with genotypes of HIV-1 in Guangxi was found . Conclusion There is no correlation between rs28919570 C / T locus polymorphism and HIV-I infection risk in Guangxi population.