论文部分内容阅读
目的探讨重度高胆红素血症的新生儿总胆红素/白蛋白的比值(B/A)与颅脑核磁(MRI)异常的关系及其临床意义。方法对象为2013年1月-2014年1月收治的足月重度高胆红素血症(血清总胆红素≥342.2μmol/L)162例,按照颅脑核磁结果,分为核磁检查正常组(126例)及核磁检查异常组(36例)。回顾性分析B/A比值与颅脑核磁的关系。结果分析结果显示:颅脑核磁异常组较颅脑核磁正常组具有更高的B/A比值,差异具有统计学意义(P<0.05)。结论高B/A比值是重度高胆红素血症患儿发生颅脑核磁异常的危险因素,可能导致患儿遗留神经行为后遗症,对于无条件行磁共振检查的基层医院通过观察B/A值,对高B/A重度高胆红素血症新生儿积极退黄疸尽可能减少其遗留神经系统后遗症的机率,并加强高危患儿的随访工作。
Objective To investigate the relationship between neonatal total bilirubin / albumin ratio (B / A) and craniocerebral MRI (MRI) abnormalities in patients with severe hyperbilirubinemia and its clinical significance. Methods Totally 162 full-term severe hyperbilirubinemia (serum total bilirubin≥342.2μmol / L) were enrolled in January 2013-January 2014. According to the results of craniocerebral magnetic resonance, the method was divided into normal group (126 cases) and abnormal MRI (36 cases). The relationship between B / A ratio and cranial magnetic resonance imaging (MRI) was retrospectively analyzed. Results The results showed that there was a higher B / A ratio in cranial magnetic anomaly group than that in normal craniocerebellar nucleus (P <0.05). Conclusions The high B / A ratio is a risk factor of cerebral magnetic anomaly in children with severe hyperbilirubinemia, which may lead to neurological behavioral sequelae in children. By observing the B / A value in the grassroots hospital without MR magnetic resonance examination, Positive high jaundice hyperbilirubinaemia hyperbilirubinemia jaundice to minimize the possibility of its remaining neurological sequelae and to strengthen the follow-up of high-risk children.