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目前,在全世界乙型肝炎病毒(HBV)携带者已达3.5亿人,其中20%～40%的人死于肝硬化和肝癌,但对于不同的自然感染有关的宿主因子了解甚少。本文作者用基因点突变技术研究了甘露糖吸附蛋白(MBP)基因突变与宿主对HBV敏感性的关系。 MBP是一种依赖于Ca~(2+)的外源凝集素,通过激活补体和促进吞噬作用,对机体抗感染的天然免疫力起重要作用。过去的研究表明,MBP基因的变异能引起成人和儿童严重而罕见的感染。HBV包膜蛋白中有MBP结合点。从Marys医院的急性和慢性HBV患者
At present, there are 350 million people with hepatitis B virus (HBV) carriers worldwide, and 20% -40% of them die of liver cirrhosis and liver cancer. However, little is known about the host factors involved in different natural infections. In this study, we used gene point mutation technique to study the relationship between MBP mutation and HBV host sensitivity. MBP is a Ca ~ (2+) -dependent lectin that plays an important role in the body’s natural immunity against infections by activating complement and promoting phagocytosis. Past studies have shown that mutations in the MBP gene can cause severe and rare infections in adults and children. HBV envelope protein MBP binding point. Acute and chronic HBV patients from Marys Hospital