论文部分内容阅读
目的探讨乳腺浸润性筛状癌(invasivecribriformcarcinoma,ICC)的临床病理和免疫表型特点。方法复习8例乳腺ICC的临床病理资料,并将其组织学特征、免疫表型和预后与浸润性导管癌进行比较。结果乳腺ICC发病平均年龄42.9岁,多表现为无痛性乳房肿块,影像学微钙化常见。组织学特征是不规则癌细胞团巢呈筛状结构浸润性生长,瘤细胞核级低～中等,多数病例核分裂象少见,胞质顶浆分泌和间质成纤维细胞增生易见,常并存筛状型导管原位癌和小管癌。免疫表型显示CK34βE12高表达而CK5/6阴性,肌上皮标记阴性。8例中经典型6例、混合型2例,其发病年龄、组织学分级、腋淋巴结转移率、cerbB2和Ki67阳性率均低于浸润性导管癌,近期随访结果显示预后优于浸润性导管癌。结论乳腺ICC作为WHO新确定的浸润性癌类型,预后较好,需要与筛状型导管原位癌和腺样囊性癌等鉴别,免疫组化染色有助于确诊。
Objective To investigate the clinicopathological features and immunophenotype of invasive invasive carcinoma of the breast (ICC). Methods The clinicopathological data of 8 cases of breast ICC were reviewed and their histological characteristics, immunophenotype and prognosis were compared with those of invasive ductal carcinoma. Results The average incidence of ICC in breast was 42.9 years old, with mostly painless breast masses. Imaging microcalcifications were common. Histological features of the irregular neoplasm of cancer cells are mesh-like infiltration of invasive growth, the tumor nucleus level is low to moderate, most cases of mitosis as rare, the secretion of cytoplasmic apoplast and stromal fibroblast proliferation is easy to see, often co-exist Type ductal carcinoma in situ and small duct cancer. Immunophenotypes showed that CK34βE12 was highly expressed but CK5 / 6 was negative, and myoepithelial markers were negative. Among the 8 cases, 6 were classic and 2 were mixed. The age, histological grade, axillary lymph node metastasis rate, positive rate of cerbB2 and Ki67 in 8 cases were lower than those in invasive ductal carcinoma. The follow-up results showed that the prognosis was better than that of invasive ductal carcinoma . Conclusion Breast ICC, as a newly identified invasive type of cancer in WHO, has a good prognosis and needs to be differentiated from those in carcinoma of the screen and adenoid cystic carcinoma. Immunohistochemical staining is helpful for the diagnosis.