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硫氧还蛋白(thioredoxins,Trx)作为一个抗氧化分子,广泛存在于多种生物体中。越来越多的研究表明,Trx在包括氧化还原调节等多种生理过程中存在广泛作用。充血性心力衰竭是多种心血管疾病的表现之一,可能通过Trx活性的抑制和活性氧的减少来降低氧化应激而使症状加剧。硫氧还蛋白互作蛋白通过抑制Trx的活性,干扰Trx绑定其他信号分子的能力,影响细胞中的葡萄糖摄取,以阻碍其生理功能。文章主要以动物体Trx为研究对象,对其分类、理化性质、生物学功能、与活性氧(reactive oxygen species,ROS)的关系及在心肌疾病能量代谢中的作用进行了阐述。
Thioredoxin (Trx), an antioxidant molecule, is found in many organisms. A growing body of research shows that Trx has a broad role in a variety of physiological processes, including redox regulation. Congestive heart failure is one of the manifestations of a variety of cardiovascular diseases and may exacerbate symptoms by reducing oxidative stress through inhibition of Trx activity and reduction of reactive oxygen species. Thioredoxin interacting proteins interfere with the ability of Trx to bind to other signaling molecules by inhibiting the activity of Trx, affecting glucose uptake in cells and hindering its physiological function. In this paper, Trx of animal body is mainly studied, and its classification, physicochemical properties, biological functions, reactive oxygen species (ROS) and its role in energy metabolism of myocardial disease are described.