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为探讨重组α干扰素 (IFNα)治疗慢性病毒性肝炎时 ,IFNα中和抗体 (NA)的产生和影响。采用抗病毒生物中和测定法检测 32 1例 IFNα治疗的慢性病毒性肝炎患者中的 NA。结果 :32 1例患者治疗前均未检出NA,治疗后检出 NA共 39例 (1 2 .1 % ) ,其中于治疗后 3、4、5和 6个月及 6个月后检出的分别为 2、6、1 1和 1 2例及 8例。NA阳性组病毒反跳率及病毒无应答率均显著高于 NA阴性组 (P<0 .0 1 )。 35例 NA阳性的患者在 NA阳性后换用天然淋巴母细胞干扰素 (IFN- αNl) ,其中病毒反跳组 1 5例中有 1 3例出现病毒阴转 ,病毒无应答组 1 8例中有 8例病毒阴转。结论 :IFNα治疗慢性病毒性肝炎 NA阳性率不高。 NA可以影响 IFNα的疗效。 NA阳性后换用 IFN-αNl有利于疗效恢复
To investigate the production and effect of IFNα neutralizing antibody (NA) in the treatment of chronic viral hepatitis with recombinant interferon α (IFNα). Antiviral bioassay was used to determine the NA in 32 1 IFNα-treated patients with chronic viral hepatitis. Results: None of the 32 patients had NA before the treatment, and 39 cases (12.1%) of NA were detected after the treatment, which were detected at 3, 4, 5, 6 and 6 months after treatment Respectively, 2, 6, 11 and 12 cases and 8 cases. The rate of virus back-up and virus non-response in NA positive group was significantly higher than that in NA negative group (P <0.01). Thirty-five NA-positive patients were switched to natural lymphoblastoid interferon (IFN-αNl) after NA positive, of which 13 cases of virus-negative were found in 15 cases of viral rebound group and 18 cases of virus-non-response group There are 8 cases of virus overcast. Conclusion: The positive rate of IFNα in treatment of chronic viral hepatitis is not high. NA can affect the efficacy of IFNα. NA positive for IFN-αNl beneficial effect recovery