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我国出产的蘿芙木(Rauwolfia verticillata(Lour.)Baill.)已有过化学和药理的报导。刘铸晉等从广西蘿芙木全硷中获得一种生物硷,称之为山馬蹄硷(samatine),它是一种季胺类型的强硷。根据其化学結构和药理的关系,作者研究了它的外周作用,特別是对N-胆硷反应系統的作用,以期闡明全硷的一些作用机制。材料和试验山馬蹄硷(C_(20)H_(25)O_3N_2Cl)盐酸盐易溶于水,是刘铸晋等从广西蘿芙木根部經离子交換剂(zeo-Karb226)获得的結晶品。猫用乙醚或氯醛醣麻醉,从靜脉注射山馬蹄硷3
Rauwolfia verticillata (Lour.) Baill., Produced in our country, has been reported chemically and pharmacologically. Liuzhuo Jin obtained a alkaloid from Guangxi Rauvulom base, called samatine, which is a quaternary ammonium base. According to its chemical structure and pharmacological relationship, the author studied its peripheral role, especially the role of the N-choline reaction system, in order to clarify some of the mechanism of the whole base. MATERIALS AND TESTS Horseshoe (C_ (20) H_ (25) O_3N_2Cl) hydrochloride is soluble in water and is a crystalline product obtained by Liuzhuo Jin et al. From zeo-Karb226. Cats were anesthetized with either ether or chloralose and were injected intravenously with horseradish