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目的:分析妊娠期高血压合并HELLP综合征患者的临床特点、生化指标、产妇并发症及母婴结局,以寻找有效的治疗方法。方法:选取该院2007年1月-2012年12月收治的妊娠期高血压合并HELLP综合征患者36例,其中完全性HELLP综合征患者19例,部分性HELLP综合征患者17例,比较两组患者的一般临床特点、生化指标、产妇并发症及母婴结局。结果:两组患者的发病孕周、分娩孕周、住院天数、产后发生HELLP的比例无统计学差异(P>0.05);两组患者的ALT、AST、LDH差异显著,P<0.05,血小板无统计学差异;两组患者的重度子痫和子痫前期的发生率、围生儿死亡的发生率具有统计学差异(P<0.05),产妇并发症和剖宫产率没有统计学差异(P>0.05)。结论:妊娠期高血压合并HELLP综合征严重影响母婴健康,尤其是完全HELLP综合征危害更为严重,目前有效的治疗方法是及时终止妊娠。
OBJECTIVE: To analyze the clinical features, biochemical indexes, maternal complications and maternal and infant outcomes in patients with Hypertension complicated with HELLP syndrome in pregnancy, in order to find an effective treatment. Methods: Thirty-six patients with gestational hypertension and HELLP syndrome admitted to our hospital from January 2007 to December 2012 were selected, including 19 patients with complete HELLP syndrome and 17 patients with partial HELLP syndrome. The general clinical characteristics of patients, biochemical indicators, maternal complications and maternal and infant outcomes. Results: There was no significant difference in gestational age, gestational age, length of hospital stay, postpartum HELLP between the two groups (P> 0.05). There was significant difference in ALT, AST and LDH between the two groups (P <0.05) The incidence of severe preeclampsia, preeclampsia and perinatal mortality were significantly different between the two groups (P <0.05). There was no significant difference in maternal complications and cesarean section rate (P> 0.05). Conclusion: Hypertension complicated with HELLP syndrome during pregnancy seriously affects maternal and infant health, especially the complete HELLP syndrome is more serious. The current effective treatment is timely termination of pregnancy.