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本文检测了60名互无血缘关系的潮州语系健康人的 HLA-A、B 抗原共28种,计算了潮州语系人群 HLA-A、B 位点的抗原频率、基因频率,及连锁不平衡的单倍型频率.初步发现潮汕语系人群的 HLA-A、B 抗原分布有不同于其他人群的一些特点,尤以All 抗原频率高的特点较为突出.在显著连锁不平衡的单倍型中,则以 A9,B60和 A2,B39两个单倍型频率较高.另外,还检测了食管癌、强直性脊柱炎、类风湿性关节炎和其它骨关节病人共142例的HLA-A、B 抗原,并研究了这些抗原与疾病的关系.结果表明除强直性脊柱炎与 B27抗原有强烈关联外,未发现其它疾病与 HLA-A、B 抗原有显著关系.本文讨论了上述结果的理论和实际意义.
In this paper, 28 HLA-A and B antigens were detected in 60 healthy individuals in Chaozhou language family who were not related to each other. The antigen frequencies, gene frequencies, and linkage disequilibrium of HLA-A and B sites in Chaozhou language population were calculated. Frequency of ploidy. It was found that the distribution of HLA-A and B antigens in Chaoshan language populations is different from other populations, especially with the high frequency of All antigens. In haplotypes with significant linkage disequilibrium, The haplotype frequencies of A9, B60, and A2 and B39 were higher. In addition, HLA-A and B antigens were detected in 142 patients with esophageal cancer, ankylosing spondylitis, rheumatoid arthritis, and other osteoarthritis patients. The relationship between these antigens and diseases was studied. The results showed that except for ankylosing spondylitis and B27 antigen, there was no significant relationship between other diseases and HLA-A and B antigens. This article discussed the theoretical and practical significance of the above results. .