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目的:分析某医院住院患者抗菌药使用情况,为合理使用抗菌药提供参考依据。方法:收集该院2006～2010年住院患者抗菌药使用记录,以限定日剂量(DDD)为单位,计算抗菌药使用强度(AUD)并进行分析。结果:该院住院患者AUD 5年间波动不大,头孢菌素类、β-内酰胺酶抑制药复合制剂和青霉素类排名AUD前3位;排名AUD前10位的药品大部分来自于头孢菌素类、β-内酰胺酶抑制药复合制剂、硝咪唑类和喹诺酮类。结论:该院可能存在用药集中、广谱抗菌药的使用率高等问题;应严格限制头孢菌素类、β-内酰胺酶抑制药复合制剂和喹诺酮类的临床应用,避免AUD的过快增长。
Objective: To analyze the use of antibacterials in inpatients in a hospital and provide a reference for rational use of antibacterials. Methods: The records of inpatients’ use of antibacterials from 2006 to 2010 in our hospital were collected. The daily dose (DDD) was used as the unit to calculate the intensity of antibacterial use (AUD) and analyzed. Results: The inpatients in this hospital did not fluctuate significantly during the first 5 years of AUD, and the top 3 were cephalosporins, β-lactamase inhibitors and penicillins. The top 10 AUD medicines came from cephalosporins Class, β-lactamase inhibitory drug combination agents, nitroimidazoles and quinolones. Conclusion: The hospital may have drug concentration, the use of broad-spectrum antimicrobial agents and other issues; should be strictly limited cephalosporins, β-lactamase inhibitors and quinolones clinical application, to avoid the excessive growth of AUD.