肿瘤坏死因子 (TNF)在充血性心衰及恶液质患者血清 (浆 )中浓度升高 ,且 TNF是一种具有负性肌力作用的前炎性介质 ,TNF-α的生物活性作用是通过结合在细胞膜表面受体 TNFR(分两型 TNFR 和 TNFR )而起作用。研究发现 ,除了细胞膜上存在 TNF受体外 ,血清中也存在 TNF受体 ,称为可溶性受体 ,分两型 :STNFR ,STNFR 。 STNFR 及 STNFR 系由 TNFR 和 TNFR 经蛋白酶剪接后进入血中而产生的。而血浆中可溶性肿瘤坏死因子受体 (STNFR)可拮抗 TNF的生物活性 ,是 TNF作用的主要调节物质 ,同时 STNFRI升高幅度可反映心功能损害的严重程度 ,另一方面 ,也是判断心衰预后的一个独立而可靠的因素 Tumor necrosis factor (TNF) levels are elevated in serum (plasma) in congestive heart failure and cachexia patients, and TNF is a proinflammatory mediator with negative inotropic effects. The biological activity of TNF-α is Works by binding to the receptor TNFR (split-type TNFR and TNFR) on the cell membrane surface. Study found that, in addition to the presence of TNF receptors on the cell membrane, serum TNF receptors also exist, called soluble receptors, two types: STNFR, STNFR. STNFR and STNFR are produced by splicing TNFR and TNFR into the blood after proteolytic cleavage. However, soluble plasma tumor necrosis factor receptor (STNFR) can antagonize the biological activity of TNF and is the main regulatory substance of TNF. Meanwhile, the increase of STNFRI can reflect the severity of cardiac dysfunction, on the other hand, An independent and reliable factor