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目的 探讨CD44V 6蛋白与鼻咽癌 (NPC )的发生、转移及预后的关系。方法 采用S -P免疫组织化学方法检测116例鼻咽癌组织中CD44基因产物的表达情况。结果 CD44蛋白表达率为 5 3 .4% (62 / 116)。CD44蛋白在有颈部淋巴结转移者中的表达率为 66.7% (4 0 / 60 ) ,高于无颈部淋巴结转移者 (3 9.3 % ) ,两者有非常显著性差异 (P <0 .0 1)。CD44V 6蛋白的表达与NPC的病理组织学分型和预后无明显关系 (P >0 .0 5 )。结论 CD44V 6蛋白的高表达与NPC颈部淋巴结转移的发生密切相关 ,提示CD 44V 6表达的上调可作为NPC患者预后判断的参考指标。
Objective To investigate the relationship between CD44V6 protein and the occurrence, metastasis and prognosis of nasopharyngeal carcinoma (NPC). Methods S-P immunohistochemistry was used to detect the expression of CD44 gene in 116 cases of nasopharyngeal carcinoma. Results The positive rate of CD44 protein was 53.4% (62/116). The positive rate of CD44 protein in patients with cervical lymph node metastasis was 66.7% (40/60), which was significantly higher than those without cervical lymph node metastasis (33.3%) (P <0. 0 1). There was no significant correlation between the expression of CD44V6 protein and histopathological type and prognosis of NPC (P> 0.05). Conclusion The high expression of CD44V6 protein is closely related to the occurrence of cervical lymph node metastasis in NPC, suggesting that the upregulation of CD44V6 expression may be used as a reference index for the prognosis of NPC.