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风行世界的生长因子、受体与致癌基因至今仍没有推广到临床应用,为此,国际抗癌联盟(UICC)肿瘤生物学部组织了一系列研讨会,以奠定分子观点的临床应用基础。生长因子Stiles综观生长因子-致癌基因领域,着重阐述了三个概念性的进展:1.发现了生长因子族,其每一成员都参与控制细胞生长、分化与发育、转化生长因子-β及多种衍生物归纳为原型生长因于族。2.生长因子受体的结构-功能分析支持这些受体的酪氨酸激酶活性对其生物活性很重要的说法。3.DNA重组术对生长因子信号转导问题的应用。Stiles总结了他的实验室在血小板生长因子(PDGF)调节基因表达方面的进展。实验表明,单一生长因子(如PDGF)至少产生两种
The popularity of growth factors, receptors, and oncogenes in the world has not yet been extended to clinical applications. To this end, the International Union Against Cancer (UICC) Department of Tumor Biology has organized a series of seminars to lay the foundation for the clinical application of molecular perspectives. The growth factor Stiles looks at the field of growth factor-oncogenes and highlights three conceptual advances: 1. The discovery of a family of growth factors, each of which participates in the control of cell growth, differentiation and development, transforming growth factor-beta, and many The derivatives are summarized as prototypes due to the family. 2. Structure-function analysis of growth factor receptors supports the claim that the tyrosine kinase activity of these receptors is important for their biological activity. 3. The application of recombinant DNA to the signal transduction of growth factors. Stiles summarized his laboratory’s progress in regulating gene expression of platelet growth factor (PDGF). Experiments have shown that a single growth factor (such as PDGF) produces at least two