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目的探讨腹腔镜手术联合米非司酮或孕三烯酮药物治疗子宫内膜异位症的临床疗效。方法 150例子宫内膜异位症患者根据治疗方法不同分为3组即腹腔镜组、腹腔镜联合米非司酮组、腹腔镜联合孕三烯酮组,每组50例。治疗6个月后随访记录3组患者症状缓解情况、月经恢复时间、药物不良反应。结果腹腔镜联合米非司酮组和腹腔镜联合孕三烯酮组总有效率明显高于腹腔镜组(P<0.05),月经恢复时间明显短于腹腔镜组(P<0.05),腹腔镜联合米非司酮组与腹腔镜联合孕三烯酮组间各项指标比较差异无统计学意义(P>0.05)。结论腹腔镜手术联合应用米非司酮或孕三烯酮治疗子宫内膜异位症,可有效降低复发,提高疗效。
Objective To investigate the clinical efficacy of laparoscopic surgery combined with mifepristone or gestrinone treatment of endometriosis. Methods One hundred and fifty cases of endometriosis patients were divided into 3 groups: laparoscopic group, laparoscopy combined with mifepristone group, laparoscopic combined gestrinone group, 50 cases in each group. After 6 months of treatment, the symptom relief, menstruation recovery time and adverse drug reaction were recorded in 3 groups. Results The total effective rate of laparoscopic combined with mifepristone group and laparoscopic combined with gestrinone group was significantly higher than that of laparoscopic group (P <0.05), and the recovery time of menstruation was significantly shorter than that of laparoscopic group (P <0.05) There was no significant difference between the combined mifepristone group and laparoscopic gestrinone group (P> 0.05). Conclusion Laparoscopic surgery combined with mifepristone or gestrinone treatment of endometriosis, can effectively reduce the recurrence and improve the efficacy.