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目的观察法舒地尔对急性心肌梗死患者心功能及心电图ST段回落的影响。方法随机双盲法将72例急性心肌梗死患者分为两组,每组36例。对照组采取常规治疗,观察组在对照组基础上加用法舒地尔治疗。观察比较两组治疗前后心功能指标、心电图ST段回落及严重心血管事件发生情况。结果观察组治疗后左室收缩末期内径(LVESD)、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)分别为(38.7±4.7)mm、(55.2±8.9)%、(59.8±3.8)mm,均显著高于对照组的(34.2±4.3)mm、(43.5±5.4)%、(53.4±4.2)mm,差异有统计学意义(P<0.05)。观察组治疗后心电图ST段回落率94.5%,显著高于对照组的75.0%,差异有统计学意义(P<0.05)。治疗后6个月内观察组严重心血管事件发生率2.8%,与对照组的16.7%比较差异有统计学意义(P<0.05)。结论法舒地尔能明显改善急性心肌梗死患者心功能,心电图ST段回落率高,严重心血管事件发生少。
Objective To observe the effects of fasudil on cardiac function and ECG ST segment depression in patients with acute myocardial infarction. Methods A total of 72 patients with acute myocardial infarction were divided into two groups by random double-blind method, 36 cases in each group. The control group to take conventional treatment, the observation group in the control group plus fasudil treatment. Before and after treatment, the comparison of cardiac function index, ECG ST segment depression and serious cardiovascular events were observed and compared. Results The LVESD, LVEF and LVEDD in observation group were (38.7 ± 4.7) mm, (55.2 ± 8.9)% and (59.8 ± 3.8 mm) were significantly higher than those in the control group (34.2 ± 4.3) mm, (43.5 ± 5.4)% and (53.4 ± 4.2) mm, respectively, with statistical significance (P <0.05). After treatment, the electrocardiogram ST segment recovery rate in the observation group was 94.5%, which was significantly higher than that in the control group (75.0%), the difference was statistically significant (P <0.05). In the 6 months after treatment, the incidence of serious cardiovascular events in the observation group was 2.8%, which was significantly different from that in the control group (16.7%) (P <0.05). Conclusion fasudil can significantly improve the cardiac function in patients with acute myocardial infarction, ECG ST segment high rate of return, less serious cardiovascular events.