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目的 探讨口服维生素 K1 对广西婴儿 VKD的控制效果。方法 360 7例活产婴随机分为干预组 1 655例 (出生～ 3月龄口服维生素 K1 2 .5mg共 1 0次 ) ,对照组 1 952例 (不用维生素 K1 ) ,观察生后 4个月内两组发生 VKDB情况。对住院分娩的足月新生儿随机抽样分别口服维生素 K1 2 .5mg、5mg及不服药各 60例 ,生后 3天测定 G- 6- PD酶活性及观察黄疸、消化道、皮肤等反应。结果 干预组无 1例发生出血 ,对照组发生 VKDB1 1例 (5.63% ,P <0 .0 1 )。口服维生素 K的足月新生儿对 G- 6- PD酶活性均无影响 (P >0 .0 5) ,无黄疸加重、过敏及胃肠道不良等反应。结论 婴儿小剂量 1 0次口服维生素 K1 预防 VKDB是简便、易行、经济、安全、有效的干预措施
Objective To investigate the effect of oral vitamin K1 on infant VKD in Guangxi. Methods Three hundred and seventy seven live births were randomly divided into intervention group (1 655 cases) (oral administration of vitamin K1 2.5 mg at birth to 3 months in total of 10 times), control group (1 952 cases without vitamin K1) and observation of 4 months after birth VKDB occurred within the two groups. Full-term newborns in hospital delivery were randomly selected oral vitamin K1 2 .5mg, 5mg and 60 cases without medication, 3 days after birth measured G-6-PD activity and observed jaundice, digestive tract, skin and other reactions. Results No bleeding occurred in 1 patient in the intervention group. VKDB1 occurred in the control group (5.63%, P <0.01). Full-term newborns with oral vitamin K had no effect on the activity of G-6-PD (P> 0.05), with no aggravating jaundice, allergic reactions, and gastrointestinal adverse reactions. Conclusions A small dose of 10 doses of oral vitamin K1 in infants to prevent VKDB is a simple, convenient, economical, safe and effective intervention