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目的:探讨大肠癌中BORIS蛋白的表达与肿瘤病理特征的关系。方法:应用免疫组织化学方法研究(60)例大肠癌组织及其配对的(40)例切缘正常大肠组织BORIS的表达情况,比较BORIS在不同大肠组织中表达的差异及其与大肠癌病理因素之间的关系。结果:大肠癌组织中BORIS蛋白表达阳性率明显高于切缘正常大肠组织(P<0.05),BORIS蛋白表达阳性率与肿瘤大小、浸润深度、Dukes分期、淋巴结转移、分化程度有关(P<0.05);与患者年龄、性别、肿瘤发生部位无关(P>0.05)。结论:BORIS过量表达可能在大肠癌的发生、发展过程中起重要作用,可能用于大肠癌辅助诊断。
Objective: To investigate the relationship between BORIS protein expression and tumor pathological features in colorectal cancer. Methods: Immunohistochemistry was used to detect the expression of BORIS in colorectal cancer tissue (60 cases) and matched normal colorectal tissues (40 cases). The expression of BORIS in different colorectal tissues was compared with that in colorectal cancer The relationship between. Results: The positive rate of BORIS protein in colorectal cancer tissues was significantly higher than that in normal colorectal tissues (P <0.05). The positive rate of BORIS protein was correlated with tumor size, depth of invasion, Dukes stage, lymph node metastasis and differentiation ), But not related to patient’s age, sex, tumor location (P> 0.05). Conclusion: Overexpression of BORIS may play an important role in the carcinogenesis and development of colorectal cancer and may be used in the diagnosis of colorectal cancer.