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目的研究抗菌药物对金双歧去除肠道产ESBLs大肠埃希菌定植效果的影响,为临床合理利用金双歧辅助治疗提供依据。方法选取崇州市人民医院2013年1月至2013年6月开展的“金双歧去除肠道产ESBLs大肠埃希菌定植的临床研究”科研项目中试验组患者102例,分成静脉使用抗菌药物组和未使用抗菌药物组,两组患者口服金双歧进行肠道内去定植。结果静脉使用抗菌药物组金双歧去除定植于肠道产ESBLs大肠埃希菌的去除率为30.30%;未使用抗菌药物组金双歧去除定植于肠道产ESBLs大肠埃希菌的去除率为41.67%。两组差异具有统计学意义(χ2=7.61,P<0.01)。结论抗菌药物对金双歧具有抑制和杀灭作用,使金双歧去除定植于肠道的产ESBLs大肠埃希菌能力减弱或消失。
Objective To study the effect of antibacterial agents on the colonization of Escherichia coli producing Escherichia coli producing gibberendogenis by gold bifidus, and to provide the basis for clinical use of gold bifid in adjuvant therapy. Methods From January 2013 to June 2013, Chongzhou Municipal People’s Hospital conducted 102 clinical trials of “Golden Bifidobacterium Escherichia coli ESBLs colonization clinical research” research projects in the pilot group of 102 patients were divided into intravenous antibiotics group And did not use antibacterial drug group, two groups of patients with oral gold Bifidobacteria to colonization. Results The removal rate of Escherichia coli ESBLs colonized by intravenous antibacterials was 30.30%. The removal rate of ESBLs-producing Escherichia coli colonizing ESBLs without antibacterial drug group was 41.67%. The difference between the two groups was statistically significant (χ2 = 7.61, P <0.01). Conclusion Antibacterial agents can inhibit and kill Jinshuangqi, and the ability of Jinshuangqi to remove ESBLs-producing Escherichia coli colonized in the gut is weakened or disappeared.