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China is a higher-intermediate hepatitis B virus (HBV) endemicity country,and HBV is among the most important infectious diseases[1,2].Hepatitis-B-associated glomerulonephritis (HBV-GN) is also one of the main forms of secondary kidney diseases seen in China[3].The main pathological type is hepatitis-B-associated membranous nephropathy (HBV-MN).In the recent years,it has been found that human renal podocyte membrane M-type phospholipase 2 receptor (PLA2R) is the main autoantigen in idiopathic membranous nephropathy (IMN)[4].At present,it is found that PLA2R and its antibodies are closely related to the pathogenesis of IMN,but the specific mechanism is still unclear.PLA2R expression also exists in secondary MN such as HBV-MN.A previous study confirmed that hepatitis B virus X gene (HBx) mutation plays an important role in the occurrence and development of HBV-GN[5].Therefore,this paper will further study the expression of PLA2R in HBV-MN and the effect of HBx gene mutation on PLA2R expression and HBV-MN and explore the possible mechanism of HBx gene mutation in PLA2R expression and pathogenesis in HBV-MN.