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甘油明胶在中国药典(1953年版,下同)中已經收載,我們参考有关文献,并根据实驗結果,对該制剂的配制法作了如下改进。 1.明胶切碎及加水量問題:明胶溶化时必須先用冷水浸漬,使軟化膨脹,已膨脹的明胶加入甘油后,稍加热即成溶液。如将干燥明胶直接加热水,常致表面軟化而中部不易吸水,形成硬块,使溶胶时間反而延长。中国药典制法中曾指出加适量的蒸溜水浸,究竟該加多少水呢?按文献記載及实驗結果,水量以加至浸沒全部明胶为宜。在制备时应将市售的明胶切成适当小碎片,然后加蒸溜水浸沒明胶。根据我們实驗結果,水温为15℃,干燥明胶厚1.5～2.5毫米,长寬为15～25平方毫米时,膨脹所需时間为1.5～2小时;厚0.5～1毫米,长寬为3～7平
Glycerol gelatin in the Chinese Pharmacopoeia (1953 edition, the same below) has been included, we refer to the literature, and based on experimental results, the formulation of the preparation made the following improvements. 1. Gelatin chopped and add water issues: gelatin melt must be immersed in cold water to soften the expansion of the expanded gelatin after adding glycerol, a little hot that is, the solution. Such as the direct heating of gelatin drying water, often caused by the surface softening of the central and not easy to absorb water, the formation of lumps, sol time extension. Chinese Pharmacopoeia has pointed out in the system of law plus the amount of distilled water immersion, after all, how much water it? According to the literature and experimental results, the amount of water added to dip all gelatin is appropriate. In the preparation of commercially available gelatin should be cut into small pieces, and then add distilled water immersion gelatin. According to our experimental results, the water temperature is 15 ℃, dried gelatin thickness 1.5 ~ 2.5 mm, length and width of 15 ~ 25 mm2, the expansion time required for 1.5 ~ 2 hours; thickness 0.5 ~ 1 mm, length and width of 3 ~ 7 flat