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目的:探讨新型脂肪因子视黄醇结合蛋白4(RBP4)与妊娠期糖尿病患者胰岛素抵抗的关系。方法:依据病例-对照设计方法,选择2010年6月~2013年6月在该院门诊及住院孕妇85例为研究对象,其中27例为正常孕妇(NGT),30例为妊娠期糖耐量异常孕妇(GIGT),28例为妊娠期糖尿病孕妇(GDM),用酶联免疫法对3组孕妇的外周血进行检测,测定3组孕妇血RBP4水平及稳态模型胰岛素抵抗指数(HOMA-IR),比较3组孕妇上述指数的差异,并利用Pearson相关分析法对血RBP4与HOMA-IR之间相关性进行检验。数据采用SPSS 13.0医用统计软件包对各组试验数据进行处理。结果:3组孕妇的血RBP4水平有统计学差异(P<0.05),其中GDM组的RBP4水平明显高于其他两组,有统计学差异(P<0.05);进行血RBP4与HOMA-IR之间的相关性检验,发现两者呈现正相关(F=9.234,P<0.05)。结论:妊娠期糖尿病患者的血RBP4水平显著增高,是其发病的危险因素之一,降低RBP4有望成为防治妊娠期糖尿病的新途径。
Objective: To investigate the relationship between RBP4 and insulin resistance in gestational diabetes mellitus (DM). Methods: According to the case-control design method, 85 outpatients and hospitalized pregnant women in our hospital from June 2010 to June 2013 were selected as the study subjects, of whom 27 were normal pregnant women (NGT), 30 were gestational impaired glucose tolerance The pregnant women (GIGT) and 28 pregnant women with gestational diabetes mellitus (GDM) were enrolled in this study. Serum RBP4 levels and HOMA-IR were measured by enzyme-linked immunosorbent assay (ELISA) The differences of the indexes between the three groups of pregnant women were compared. Pearson correlation analysis was used to test the correlation between blood RBP4 and HOMA-IR. The data were processed using the SPSS 13.0 medical statistics package for each set of experimental data. Results: RBP4 levels in GDM group were significantly higher than those in the other two groups (P <0.05), RBP4 level in blood of pregnant women was significantly different (P <0.05) The correlation test showed that there was a positive correlation between them (F = 9.234, P <0.05). Conclusion: The level of blood RBP4 in gestational diabetes mellitus patients is significantly increased, which is one of the risk factors for its pathogenesis. To reduce RBP4 is expected to become a new way to prevent and treat gestational diabetes mellitus.