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目的 探讨儿童多发性硬化 (MS)的临床特点。方法 对 1990～ 2 0 0 1年住院的 6例MS患儿的临床表现、辅助检查进行分析。结果 5例以肢体瘫痪为首发症状 ,1例以语言障碍为首发症状 ;典型症状包括肢体瘫痪5例 ,视觉障碍、感觉障碍、横断性脊髓损害、括约肌障碍各 3例 ,小脑性共济失调 2例 ;伴随症状包括头痛、视乳头水肿、嗜睡、发热、眼球运动障碍。脑电图 5例异常 ,诱发电位 2例异常 ,CT 2例异常 ,MR 5例异常 ,脑脊液 2例异常。结论 儿童MS起病急 ,症状多样化 ,球后视神经炎在MS诊断中具有一定意义 ,MR较CT对MS诊断意义更大。
Objective To investigate the clinical features of childhood multiple sclerosis (MS). Methods The clinical manifestations and laboratory tests of 6 MS children admitted to hospital from 1990 to 2001 were analyzed. Results Five cases had limb paralysis as the first symptom and one case had speech disorder as the first symptom. Typical symptoms included limb paralysis in 5 cases, visual impairment, sensory disturbance, transection spinal cord injury, sphincter dysfunction in 3 cases, cerebellar ataxia 2 Cases; associated symptoms include headache, papilledema, drowsiness, fever, eye movement disorders. There were 5 cases of EEG abnormality, 2 cases of evoked potential abnormalities, 2 cases of CT abnormalities, 5 cases of MR abnormalities and 2 cases of cerebrospinal fluid abnormalities. Conclusion Children with acute onset of MS, the diversity of symptoms, retrobulbar optic neuritis in the diagnosis of MS has a certain significance, MR than CT on the diagnosis of MS greater significance.