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葡萄糖转位载体4(GLUT4)转位的受损与2型糖尿病密切相关,所以筛选促进GLUT4转位的药物并研究其相关的信号通路对治疗2型糖尿病具有十分重要的意义。药物促进GLUT4转位主要通过AMP活化蛋白激酶(AMPK)、磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)和蛋白激酶C(PKC)信号通路。本文分别介绍了这三种信号通路与GLUT4转位的关系以及相关的促进GLUT4转位的药物,为寻找治疗2型糖尿病的潜在新药提供参考。
The impaired translocation of glucose transporter 4 (GLUT4) is closely related to type 2 diabetes. Therefore, screening out drugs that promote GLUT4 translocation and studying their related signaling pathways are of great importance in the treatment of type 2 diabetes. Drugs promote GLUT4 translocation via AMPK, PI3K / Akt, and PKC signaling. This article describes the relationship between these three signaling pathways and the translocation of GLUT4 and the related drugs that promote the translocation of GLUT4, respectively, to provide a reference for finding potential new drugs for the treatment of type 2 diabetes.