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目的:探讨SLE患者抗β2GPⅠ抗体及抗心磷脂抗体亚型与血脂水平和凝血酶原时间之间的关系。方法:收集2006年8月至2007年1月我院确诊的SLE患者血液标本41例,采用ELISA法测定血清中ACA亚型及aβ2GPⅠ水平,同时检测ds-DNA、TG、CH、APTT、PT等相关指标。结果:⑴41例SLE患者中aβ2GPⅠ升高者10例(24.4%),ACA-IgG阳性者20例(48.8%),ACA-IgA阳性者7例(17.1%),与正常对照组比较差异均有显著性意义(P分别<0.001或<0.05);⑵10例aβ2GPⅠ阳性SLE患者中有4例同时存在ACA阳性,其中3例为同时ACA-IgG、ACA-IgA阳性,1例为ACA-IgG阳性。41例SLE患者aβ2GPⅠ阳性率与ACA-IgG、ACA-IgA比较差异无显著性意义(P均>0.05);⑶伴有继发性磷脂综合征的SLE和无继发性磷脂综合征SLE患者相关指标的比较,差异均无显著性意义(P均>0.05);⑷41例SLE患者ds-DNA、TG、CH、APTT、PT与aβ2GPⅠ和ACA亚型进行相关性分析,结果CH与ACA-IgA存在正相关,r=2.66,P<0.05;APTT与ACA-IgG存在负相关,r=-0.313,P<0.05。结论:结果提示抗β2GPⅠ抗体可作为SLE继发APS的诊断指标,联合ACA检测将会提高检测率。
Objective: To investigate the relationship between anti-β2GPⅠ antibody and anti-cardiolipin antibody subtype in patients with SLE and serum lipids and prothrombin time. Methods: Totally 41 blood samples from patients with SLE diagnosed in our hospital from August 2006 to January 2007 were collected. Serum levels of ACA subtype and aβ2GPⅠ were measured by ELISA, and ds-DNA, TG, CH, APTT and PT Related indicators. Results (1) Twenty-one cases (24.8%) were positive for aβ2GPⅠ, 20 cases (48.8%) were positive for ACA-IgG and 7 cases (17.1%) were positive for ACA-IgA in 41 cases of SLE patients (P <0.001 or <0.05, respectively). (2) In 4 out of 10 aβ2GPⅠ-positive SLE patients, there were both ACA-positive and ACA-IgG positive, ACA-IgA positive and ACA-IgG positive in 3 cases. The positive rate of aβ2GPⅠ in 41 SLE patients was not significantly different from that of ACA-IgG and ACA-IgA (all P> 0.05) .③The correlation between SLE with secondary phospholipid syndrome and SLE without secondary phospholipid syndrome (P> 0.05). (4) The correlation analysis of ds-DNA, TG, CH, APTT, PT and aβ2GPⅠ and ACA subtypes in 41 patients with SLE showed that there was CH and ACA-IgA R = 2.66, P <0.05; There was a negative correlation between APTT and ACA-IgG, r = -0.313, P <0.05. Conclusion: The results suggest that anti-β2GPⅠ antibody can be used as a secondary diagnostic criteria for SLE APS, combined with ACA test will increase the detection rate.