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本文对３０例大肠癌细胞的胞浆和胞核部分作了雌激素受体（ＥＲ）测定，结合临床和病理分析，对肠癌组织中雌激素受体存在的意义进行了讨论，结果显示：在大肠癌组织中，存在ＥＲ，其中胞浆ＥＲ（ＥｃＲ）含量为６．０６９±４．７７６ｍｏｌ／ｍｇ蛋白；胞核ＥＲ（ＥｎＲ）含量为４２．７９±８·５７ｆｍｏｌ／ｍｇ蛋白，两者比较有明显差异（ｐ＜０．００５）。ＥＲ在胞浆中的阳性率为２６．６７％，胞核的阳性率为６６．６７％；女性ＥｎＲ阳性率为（８０％）高于男性（４０％）（Ｐ＜０．０５）；ＥＲ在胞浆及胞核中分布呈“异质性”二者表达相符率为４０％，不相符率为６０％（Ｐ＜０．０５）。大肠癌在组织学分级与ＥｎＲ阳性率有明显关系，分化好的肿瘤（Ⅰ、Ⅱ级），ＥｎＲ阳性率有高于分化差者（Ⅲ级）（Ｐ＜０．０５），而ＥｎＲ的含量亦随着分化程度降低而降低（Ｐ＞０．０５）。
In this paper, estrogen receptor (ER) was measured in cytoplasm and nucleus of 30 colorectal cancer cells. Combined with clinical and pathological analysis, the significance of estrogen receptors in colorectal cancer was discussed. The results showed that: In colorectal cancer, there is ER, in which cytosolic ER (EcR) content is 6.069±4.776 mol/mg protein; nucleus ER (EnR) content is 42.79±8·57 fmol/mg protein, both There were significant differences (p<0.005). The positive rate of ER in cytoplasm was 26.67% and the positive rate of nucleus was 66.67%; female EnR positive rate was (80%) higher than that of male (40%) (P<0.05); ER In the cytoplasm and nucleus, the distribution of “heterogeneity” showed a coincidence rate of 40%, and the inconsistency rate was 60% (P <0.05). There was a significant relationship between histological grade and EnR positive rate in colorectal cancer. The positive rate of EnR positive tumors was higher in well-differentiated tumors (grades I and II) than in poorly differentiated patients (grade III) (P<0.05). It also decreased as the degree of differentiation decreased (P>0.05).