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[目的]探索铝碳酸镁联合奥美拉唑治疗内镜黏膜下剥离术后人造溃疡的疗效。[方法]选取2012年4月~2015年2月在我院进行内镜黏膜下剥离术的64例患者,分为研究组和对照组进行对比分析,研究组32例,在常规治疗基础上使用铝碳酸镁、奥美拉唑联合治疗,对照组32例仅使用奥美拉唑进行治疗。主要对比观察手术后患者对药物的上腹部症状、溃疡变化的反应及不良反应发生率。[结果]手术后第1天2组均出现饱胀、上腹疼痛等症状,差异无统计学的意义;而手术后的第3、7天研究组上腹部的症状评分都优于对照组。手术后的第1周愈合率和溃疡的直径比较差异无统计学的意义,而第4周研究组的愈合率和溃疡直径的情况都优于对照组。[结论]使用铝碳酸镁联合奥美拉唑治疗内镜黏膜下剥离术后人造溃疡的疗效较单独使用奥美拉唑更加显著,既不增加不良反应,又能有效改善内镜黏膜下剥离术后上腹的症状,促进手术之后人造溃疡的愈合。
[Objective] To explore the curative effect of hydrotalcite combined with omeprazole on artificial ulcer after endoscopic submucosal dissection. [Methods] Sixty-four patients with endoscopic submucosal dissection in our hospital from April 2012 to February 2015 were divided into study group and control group for comparative analysis. The study group consisted of 32 patients who were treated on the basis of routine treatment Aluminum magnesium carbonate, omeprazole combined treatment, control group, 32 cases were treated with omeprazole only. The main contrastive observation of patients after surgery for the symptoms of upper abdominal drugs, ulcer changes and the incidence of adverse reactions. [Results] The symptoms of fullness and upper abdominal pain appeared on the first day after operation. There was no significant difference between the two groups on the first day after surgery. On the 3rd and 7th day after operation, the symptom scores of the upper abdomen were better than those of the control group. There was no significant difference between the healing rate and the diameter of the ulcer in the first week after operation, while the healing rate and ulcer diameter of the study group in the fourth week were better than those in the control group. [Conclusion] The use of magnesium aluminum carbonate combined with omeprazole in the treatment of artificial ulcers after endoscopic submucosal dissection is more effective than omeprazole alone. It not only increases the adverse reaction, but also effectively improves the endoscopic submucosal dissection Post-abdominal symptoms promote the healing of artificial ulcers after surgery.