近10余年,对肝脏病免疫发病的机理做了大量研究工作,积累了丰富的资料.70年代后期,由于单克隆抗体技术的出现,进一步促进了肝脏病细胞免疫的研究.以前着重研究外周血单个核细胞介导的细胞毒,现在已把研究重点转向肝内浸润的单个核细胞.在靶细胞方面,用异体肝细胞进行细胞毒试验,不能满足HLA的 In the past 10 years, a great deal of research work has been done on the mechanism of the pathogenesis of liver disease, and accumulated a wealth of information. In the late 1970s, due to the appearance of monoclonal antibody technology, the study of liver cell immunity was further promoted. Mononuclear cell-mediated cytotoxicity has now shifted the focus of research to intrahepatic infiltration of mononuclear cells.In the target cells, cytotoxicity test with allogeneic hepatocytes can not meet the HLA