论文部分内容阅读
目的:监测放射性~(125)I粒子植入家兔正常喉组织后不同时间周围辐射剂量的变化,从辐射防护角度探讨其临床应用的安全性。方法:健康雄性普通级新西兰家兔60只,重2.15~2.30kg,随机分为7d组、1个月组、2个月组、4个月组及对照组,每组12只。分别将3粒活度为0.8mCi/粒、半衰期60.2d的放射性~(125)I粒子植入实验组家兔右侧第一气管环旁。测量实验组4个月亚组植入粒子后不同时间、不同距离的周围辐射剂量,对结果进行统计学处理。结果:随着与粒源距离的增加及植入后时间的延长,周围辐射剂量减少,且随着距离的增加,周围辐射剂量下降缓慢,在距离粒源1m处,测得剂量为室内天然本底辐射剂量。结论:放射性~(125)I粒子组织间植入治疗临床应用易于防护,其周围密切接触者是安全的。
OBJECTIVE: To monitor the change of radiation dose at different time after implantation of radioactive 125 I seeds into normal laryngeal tissues in rabbits, and to explore the safety of its application in radiation protection. Methods: Sixty healthy New Zealand male rabbits weighing 2.15 ~ 2.30kg were randomly divided into 7d group, 1 month group, 2 months group, 4 months group and control group, 12 in each group. Three radioactive (125) I particles with an activity of 0.8 mCi / particle and a half-life of 60.2 d were implanted into the right trachea of the right trachea in the experimental group respectively. The experimental group 4 months after sub-group implantation of particles at different times and different distances around the radiation dose, the results were statistically analyzed. Results: With the increase of the distance from the grain source and the extension of the time after implantation, the radiation dose decreased, and with the increase of the distance, the radiation dose decreased slowly. At the distance of 1m from the grain source, the measured dose was the indoor natural Bottom radiation dose. CONCLUSION: Radioactive 125 I seed implantation is an effective and safe method for the clinical application. It is safe for the close contacts.