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目的通过对布病患者不同疾病阶段的免疫学指标进行检测,结合其流行病学特点及临床表现进行综合分析,为降低该疾病的误诊率提供一定参考价值。方法对2013年1月至2014年12月在太原市传染病医院接受治疗的布病患者的流行病学特征、临床表现及相关免疫学指标进行分析。结果布病患者血清中Ig G、Ig M的阳性率分别为91.0%、39.1%,随着疾病分期由急性向慢性的转变,血清中Ig G水平逐渐升高,而Ig M水平逐渐降低;有73.1%的布病患者血清中CRP水平超过正常值范围,随着患者疾病分期由急性向慢性转变,CRP水平明显降低。结论结合布病患者的流行病学特征及临床表现,检测血清中Ig M及CRP水平可降低急性期患者的误诊率,而检测Ig G水平对慢性布病患者的诊断具有一定参考价值。
OBJECTIVE To provide a reference value for reducing the misdiagnosis rate of the disease by comprehensively analyzing the immunological indexes of patients with brucellosis at different disease stages and combining their epidemiological characteristics and clinical manifestations. Methods The epidemiological characteristics, clinical manifestations and related immunological parameters of brucellosis patients who were treated in Taiyuan Infectious Disease Hospital from January 2013 to December 2014 were analyzed. Results The positive rates of Ig G and Ig M in the sera from patients with brucellosis were 91.0% and 39.1% respectively. As the stage of disease changed from acute to chronic, Ig G level in serum gradually increased and Ig M level decreased gradually Serum levels of CRP in 73.1% of brucellosis patients exceeded the normal range, with CRP levels declining significantly as the disease stage progressed from acute to chronic. Conclusions Combined with the epidemiological characteristics and clinical manifestations of brucellosis patients, detecting serum IgM and CRP level can reduce the misdiagnosis rate in acute stage, while detecting IgG level has some reference value for the diagnosis of chronic brucellosis.