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目的通过分组对比分析血清β-人绒毛膜促性腺激素(β-hCG)、糖类抗原125(CA125)及孕酮(P)联合检查对预测先兆流产结局的价值。方法以襄阳市妇幼保健院2014年1月-2016年6月收治的先兆流产孕妇187例作为研究对象,依照妊娠结局,将难免流产者设为流产组(62例)、将继续妊娠者设为妊娠组(125例),并以同期正常妊娠的孕妇90例作为对照组。采用化学发光法检测187例患者血清β-hCG、CA125和P水平,对各组检测结果进行对比分析。结果流产组和妊娠组的CA125水平较对照组均显著升高,而流产组CA125水平较妊娠组显著升高;流产组和妊娠组β-hCG和P水平较对照组显著降低,而流产组β-hCG和P水平均较妊娠组显著降低。正常组和妊娠组间隔48 h的β-hCG和P水平均呈现上升趋势,且大部分患者β-hCG增幅>50%;而流产组间隔48 hβ-hCG水平仅有21.0%出现上升,且全组P水平均呈下降趋势;流产组79%的患者β-hCG和P水平同时下降。结论孕妇血清β-hCG、CA125和P联合检测并动态监测其间隔48 h血清β-hCG和P水平变化趋势,对预测早期先兆流产结局具有重要意义。
Objective To compare the value of β-hCG, CA125 and progesterone in predicting the outcome of threatened abortion. Methods A total of 187 threatened abortion pregnant women who were treated in Xiangyang MCH from January 2014 to June 2016 were selected as the study subjects. According to the pregnancy outcome, 62 cases of unavoidable abortion were defined as abortion group, Pregnancy group (n = 125), 90 pregnant women with normal pregnancy in the same period as control group. The serum levels of β-hCG, CA125 and P in 187 patients were detected by chemiluminescence method, and the results of each group were compared and analyzed. Results The levels of CA125 in abortion group and pregnancy group were significantly higher than those in control group, while the level of CA125 in abortion group was significantly higher than that in pregnancy group. The levels of β-hCG and P in abortion group and pregnancy group were significantly lower than those in control group -hCG and P levels were significantly lower than those in pregnancy group. The levels of β-hCG and P in the normal group and the pregnant group increased at an interval of 48 h, and the increase of β-hCG in most of the patients was> 50%. However, only 21.0% of 48 h increased in the abortion group, Group P levels showed a downward trend; 79% of patients with abortion group β-hCG and P levels decreased at the same time. Conclusion The combination of serum β-hCG, CA125 and P in pregnant women and the dynamic monitoring of serum β-hCG and P levels in 48 h intervals are of great significance in predicting the outcome of early threatened abortion.