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通过树状接枝聚己内酯的侧羟基及端羟基与氯甲酰化的聚乙二醇进行接枝反应,得到带有亲水性聚乙二醇链段的新型两亲性树状接枝共聚物.1H-NMR分析显示,接枝率为50%左右.GPC分析结果表明,共聚物分子量呈较窄的单峰分布,分子量与接枝前相比明显增高.两亲性共聚物能直接分散在水中形成胶束溶液.以芘为荧光探针的测试结果表明其临界胶束浓度有降低.动态光散射测得胶束平均粒径在16至31 nm之间,粒径分散指数适中,PDI在0.25至0.39之间.TEM显示胶束粒子为不规整球形,由更小的粒径为几个纳米的微粒聚集而成,这些微粒的大小刚好与单个大分子的尺寸相匹配.因此,两亲性树状接枝聚己内酯在水相中存在单分子胶束与多分子组装胶束的平衡.得益于支化聚合物结构中的纳米空腔,两亲性树状接枝聚合物胶束对紫杉醇具有优良的包载能力.
Through the graft reaction of the side hydroxyl groups and terminal hydroxyl groups of the dendrimer polycaprolactone with the chloroformylated polyethylene glycol, a novel amphipathic dendron with hydrophilic polyethylene glycol segments was obtained 1 H-NMR analysis showed that the grafting rate was about 50% .GPC analysis showed that the copolymer molecular weight showed a narrow single peak distribution, the molecular weight was significantly increased compared with the pre-grafted amphiphilic copolymer Directly dispersed in water to form a micellar solution.The test results of pyrene as a fluorescent probe showed that the critical micelle concentration decreased.And the mean particle size of micelles was between 16 and 31 nm by dynamic light scattering and the particle size dispersion index was moderate , With a PDI between 0.25 and 0.39. TEM shows that the micellar particles are irregularly spherical and consist of smaller particles of a few nanometers in size that are exactly the size of a single macromolecule. , The amphiphilic dendritic polycaprolactone has the balance between single-molecule micelles and multi-molecularly assembled micelles in the aqueous phase.Because of the nano-cavity in the branched polymer structure, amphipathic dendritic Branched polymer micelles have good loading capacity for paclitaxel.